La Banda Sonora de Kyle XY salió a la venta el 22 de mayo de 2007 en Estados Unidos. La lista de canciones es la siguiente:

01. Hide Another Mistake - The 88.
02. Nevermind the Phonecalls - Earlimart.
03. Surround - In-Flight Safety.
04. I'll Write the Song, You Sing For Me - Irving.
05. Wonderful Day - O.A.R..
06. Bug Bear - Climber.
07. Honestly - Cary Brothers.
08. So Many Ways - Mates of State.
09. Middle Of the Night - Sherwood.
10. Alibis - Marianas Trench.
11. It's Only Life - Kate Voegele.
12. 3:00 A.M. - Sean Hayes.
13. Born On the Cusp - American Analog Set.
14. Will You Remember Me (Lori's Song) - April Matson.